Effect of Various Environmental /processing Factors on Stability of the Formulation and Techniques for Stabilization of Products against the Same

 BLENDING: It is most important step for manufacturing of solution dosage form. High speed of mixing may introduce air into the product and slow mixing may not form a satisfactory product.  For mixing step, both mixing time and speed should be evaluated for API and Excipients.  Mixing might produce particle size reduction or polymorphic conversion  During mixing some other factors like type of agitator, temperature or vaccum etc. can affect the stability.  Say for example, if during mixing, vacuum is not applied than air bubble will present into the product that might produce oxidation of product.